One of the best things I’ve done for my hands was making sure that at night they take a proper break. Granted, I only really give them a break while I sleep, but it turns out that churning out all kinds of amigurumi while awake was contributing to tightness and clenching while I was sleeping - so they weren’t REALLY resting while I was sleeping. I would wake up and my hands would be MORE sore than they were when I finished crocheting all day.
I solved this by buying a set of wrist and hand braces for night time use. I bought THIS kind and it has served me very well. The important parts are that it stabilizes my wrist, while still being comfortable and NOT TOO TIGHT for night time use. And additionally, it has padding on the palm of the brace that does not allow me to clench my hand into a fist while I sleep. This forces my hand to stay in a relaxed position.
On top of that, I often use an athletic cream for sore muscles or a CBD cream on my hands, then I put my hands in those braces over night and by morning I always feel an improvement.
The bad news is that I, personally, have a hard time sleeping with those wrist braces on. But they’re good for me, so I grumble through it. I hope this helps!